Focusing firmly on the patient, digital approaches can theoretically transform the research landscape, enabling better, faster and more efficient clinical trials. These technologies will enable conducting a less complex interventional and observational study involving chronic disease. For patients, expansion of clinical care options, improved trial accessibility, enhanced retention are the key advantages. Whereas for investigators, a richer data from a diverse population will give deeper insights about the condition. Virtual clinical trials are likely to enhance the patient and investigator satisfaction in the clinical study. However, virtual trials also demand various complex regulatory requirements and in-depth clinical understanding.